| 2022-01-15 12:30:0001/15/2022 | London Knights  | 28 - 41 |  Baltimore Vultures | N/A |
| 2022-01-15 13:05:0001/15/2022 | Los Angeles Lycans  | 31 - 28 |  Charleston Predators | N/A |
| 2022-01-15 14:45:0001/15/2022 | Arizona Scorpions  | 30 - 14 |  Tulsa Desperados | N/A |
| 2022-01-15 15:15:0001/15/2022 | Sioux Falls Sparrows  | 12 - 34 |  Louisiana Revolution | N/A |
| 2022-01-15 19:30:0001/15/2022 | Vancouver Legion  | 42 - 37 |  Carolina Skyhawks | N/A |
| 2022-01-15 19:50:0001/15/2022 | St. Louis Gladiators  | 31 - 27 |  Las Vegas Fury | N/A |
| 2022-01-16 13:00:0001/16/2022 | Florida Storm  | 17 - 24 |  San Diego Mavericks | N/A |
| 2022-01-16 13:35:0001/16/2022 | Houston Hyenas  | 15 - 20 |  D.C. Dragons | N/A |
| 2022-01-16 15:10:0001/16/2022 | Jacksonville Kings  | 34 - 27 |  Portland Fleet | N/A |
| 2022-01-16 15:45:0001/16/2022 | Atlanta Swarm  | 30 - 24 |  Denver Nightwings | N/A |
| 2022-01-16 18:00:0001/16/2022 | Mexico City Aztecs  | 41 - 38 |  Fort Worth Toros | N/A |
| 2022-01-16 18:20:0001/16/2022 | Queen City Corsairs  | 17 - 35 |  Lone Star Glory | N/A |
| 2022-01-22 12:30:0001/22/2022 | Lone Star Glory | 12:30:0012:30 pm EST | London Knights | N/A |
| 2022-01-22 13:05:0001/22/2022 | Tulsa Desperados | 13:05:001:05 pm EST | Las Vegas Fury | N/A |
| 2022-01-22 14:45:0001/22/2022 | Carolina Skyhawks | 14:45:002:45 pm EST | San Diego Mavericks | N/A |
| 2022-01-22 15:15:0001/22/2022 | Los Angeles Lycans | 15:15:003:15 pm EST | Vancouver Legion | N/A |
| 2022-01-22 17:30:0001/22/2022 | Louisiana Revolution | 17:30:005:30 pm EST | Denver Nightwings | N/A |
| 2022-01-22 17:50:0001/22/2022 | Baltimore Vultures | 17:50:005:50 pm EST | Houston Hyenas | N/A |
| 2022-01-24 14:30:0001/24/2022 | Jacksonville Kings | 14:30:002:30 pm EST | Charleston Predators | N/A |
| 2022-01-24 14:50:0001/24/2022 | Sioux Falls Sparrows | 14:50:002:50 pm EST | St. Louis Gladiators | N/A |
| 2022-01-24 16:30:0001/24/2022 | Arizona Scorpions | 16:30:004:30 pm EST | Atlanta Swarm | N/A |
| 2022-01-24 16:50:0001/24/2022 | Mexico City Aztecs | 16:50:004:50 pm EST | Queen City Corsairs | N/A |
| 2022-01-24 18:30:0001/24/2022 | Portland Fleet | 18:30:006:30 pm EST | Florida Storm | N/A |
| 2022-01-24 18:50:0001/24/2022 | D.C. Dragons | 18:50:006:50 pm EST | Fort Worth Toros | N/A |
| 2022-01-29 12:00:0001/29/2022 | Denver Nightwings | 12:00:0012:00 pm EST | Sioux Falls Sparrows | N/A |
| 2022-01-29 12:20:0001/29/2022 | D.C. Dragons | 12:20:0012:20 pm EST | Lone Star Glory | N/A |
| 2022-01-29 14:30:0001/29/2022 | Vancouver Legion | 14:30:002:30 pm EST | Jacksonville Kings | N/A |
| 2022-01-29 15:00:0001/29/2022 | Baltimore Vultures | 15:00:003:00 pm EST | Fort Worth Toros | N/A |
| 2022-01-29 16:45:0001/29/2022 | London Knights | 16:45:004:45 pm EST | Mexico City Aztecs | N/A |
| 2022-01-29 17:15:0001/29/2022 | Tulsa Desperados | 17:15:005:15 pm EST | Louisiana Revolution | N/A |
| 2022-01-30 13:00:0001/30/2022 | Queen City Corsairs | 13:00:001:00 pm EST | Houston Hyenas | N/A |
| 2022-01-30 13:20:0001/30/2022 | St. Louis Gladiators | 13:20:001:20 pm EST | Atlanta Swarm | N/A |
| 2022-01-30 15:00:0001/30/2022 | Charleston Predators | 15:00:003:00 pm EST | Portland Fleet | N/A |
| 2022-01-30 15:20:0001/30/2022 | Carolina Skyhawks | 15:20:003:20 pm EST | Florida Storm | N/A |
| 2022-01-30 17:00:0001/30/2022 | San Diego Mavericks | 17:00:005:00 pm EST | Los Angeles Lycans | N/A |
| 2022-01-30 17:20:0001/30/2022 | Las Vegas Fury | 17:20:005:20 pm EST | Arizona Scorpions | N/A |
| 2022-02-05 14:30:0002/05/2022 | Fort Worth Toros | 14:30:002:30 pm EST | Queen City Corsairs | N/A |
| 2022-02-05 15:05:0002/05/2022 | Vancouver Legion | 15:05:003:05 pm EST | Charleston Predators | N/A |
| 2022-02-05 16:45:0002/05/2022 | Florida Storm | 16:45:004:45 pm EST | Los Angeles Lycans | N/A |
| 2022-02-05 17:15:0002/05/2022 | Mexico City Aztecs | 17:15:005:15 pm EST | D.C. Dragons | N/A |
| 2022-02-06 19:00:0002/06/2022 | Portland Fleet | 19:00:007:00 pm EST | Carolina Skyhawks | N/A |
| 2022-02-06 19:20:0002/06/2022 | Denver Nightwings | 19:20:007:20 pm EST | Tulsa Desperados | N/A |
| 2022-02-06 21:00:0002/06/2022 | Sioux Falls Sparrows | 21:00:009:00 pm EST | Las Vegas Fury | N/A |
| 2022-02-06 21:20:0002/06/2022 | Louisiana Revolution | 21:20:009:20 pm EST | Arizona Scorpions | N/A |
| 2022-02-12 14:30:0002/12/2022 | Mexico City Aztecs | 14:30:002:30 pm EST | Baltimore Vultures | N/A |
| 2022-02-12 15:05:0002/12/2022 | St. Louis Gladiators | 15:05:003:05 pm EST | Denver Nightwings | N/A |
| 2022-02-12 16:45:0002/12/2022 | Louisiana Revolution | 16:45:004:45 pm EST | Atlanta Swarm | N/A |
| 2022-02-12 17:15:0002/12/2022 | Lone Star Glory | 17:15:005:15 pm EST | Houston Hyenas | N/A |
| 2022-02-14 19:00:0002/14/2022 | Fort Worth Toros | 19:00:007:00 pm EST | London Knights | N/A |
| 2022-02-14 19:20:0002/14/2022 | Carolina Skyhawks | 19:20:007:20 pm EST | Jacksonville Kings | N/A |
| 2022-02-14 21:00:0002/14/2022 | Tulsa Desperados | 21:00:009:00 pm EST | Sioux Falls Sparrows | N/A |
| 2022-02-14 21:20:0002/14/2022 | Portland Fleet | 21:20:009:20 pm EST | San Diego Mavericks | N/A |
| 2022-02-19 14:30:0002/19/2022 | Houston Hyenas | 14:30:002:30 pm EST | Fort Worth Toros | N/A |
| 2022-02-19 15:00:0002/19/2022 | Denver Nightwings | 15:00:003:00 pm EST | Arizona Scorpions | N/A |
| 2022-02-19 16:45:0002/19/2022 | San Diego Mavericks | 16:45:004:45 pm EST | Charleston Predators | N/A |
| 2022-02-19 17:15:0002/19/2022 | Las Vegas Fury | 17:15:005:15 pm EST | Louisiana Revolution | N/A |
| 2022-02-20 17:00:0002/20/2022 | London Knights | 17:00:005:00 pm EST | D.C. Dragons | N/A |
| 2022-02-20 17:20:0002/20/2022 | Atlanta Swarm | 17:20:005:20 pm EST | Sioux Falls Sparrows | N/A |
| 2022-02-20 19:00:0002/20/2022 | Lone Star Glory | 19:00:007:00 pm EST | Mexico City Aztecs | N/A |
| 2022-02-20 19:20:0002/20/2022 | Tulsa Desperados | 19:20:007:20 pm EST | St. Louis Gladiators | N/A |
| 2022-02-20 21:00:0002/20/2022 | Florida Storm | 21:00:009:00 pm EST | Vancouver Legion | N/A |
| 2022-02-20 21:20:0002/20/2022 | Jacksonville Kings | 21:20:009:20 pm EST | Los Angeles Lycans | N/A |
| 2022-02-21 19:15:0002/21/2022 | Baltimore Vultures | 19:15:007:15 pm EST | Queen City Corsairs | N/A |
| 2022-02-26 14:30:0002/26/2022 | Baltimore Vultures | 14:30:002:30 pm EST | Lone Star Glory | N/A |
| 2022-02-26 15:00:0002/26/2022 | Arizona Scorpions | 15:00:003:00 pm EST | St. Louis Gladiators | N/A |
| 2022-02-26 16:45:0002/26/2022 | Charleston Predators | 16:45:004:45 pm EST | Florida Storm | N/A |
| 2022-02-26 17:15:0002/26/2022 | D.C. Dragons | 17:15:005:15 pm EST | Queen City Corsairs | N/A |
| 2022-02-27 19:00:0002/27/2022 | Los Angeles Lycans | 19:00:007:00 pm EST | Carolina Skyhawks | N/A |
| 2022-02-27 19:20:0002/27/2022 | San Diego Mavericks | 19:20:007:20 pm EST | Jacksonville Kings | N/A |
| 2022-02-27 21:00:0002/27/2022 | Atlanta Swarm | 21:00:009:00 pm EST | Las Vegas Fury | N/A |
| 2022-02-27 21:20:0002/27/2022 | Portland Fleet | 21:20:009:20 pm EST | Vancouver Legion | N/A |
| 2022-02-28 19:15:0002/28/2022 | London Knights | 19:15:007:15 pm EST | Houston Hyenas | N/A |
| 2022-03-05 14:30:0003/05/2022 | Queen City Corsairs | 14:30:002:30 pm EST | Arizona Scorpions | N/A |
| 2022-03-05 15:00:0003/05/2022 | Sioux Falls Sparrows | 15:00:003:00 pm EST | D.C. Dragons | N/A |
| 2022-03-05 16:45:0003/05/2022 | Lone Star Glory | 16:45:004:45 pm EST | Los Angeles Lycans | N/A |
| 2022-03-05 17:15:0003/05/2022 | Fort Worth Toros | 17:15:005:15 pm EST | Vancouver Legion | N/A |
| 2022-03-06 19:00:0003/06/2022 | Denver Nightwings | 19:00:007:00 pm EST | London Knights | N/A |
| 2022-03-06 19:20:0003/06/2022 | Mexico City Aztecs | 19:20:007:20 pm EST | Portland Fleet | N/A |
| 2022-03-06 21:00:0003/06/2022 | Carolina Skyhawks | 21:00:009:00 pm EST | Louisiana Revolution | N/A |
| 2022-03-06 21:20:0003/06/2022 | Charleston Predators | 21:20:009:20 pm EST | Tulsa Desperados | N/A |
| 2022-03-12 14:30:0003/12/2022 | Jacksonville Kings | 14:30:002:30 pm EST | Atlanta Swarm | N/A |
| 2022-03-12 15:00:0003/12/2022 | Fort Worth Toros | 15:00:003:00 pm EST | San Diego Mavericks | N/A |
| 2022-03-12 16:45:0003/12/2022 | Vancouver Legion | 16:45:004:45 pm EST | Mexico City Aztecs | N/A |
| 2022-03-12 17:15:0003/12/2022 | Portland Fleet | 17:15:005:15 pm EST | Lone Star Glory | N/A |
| 2022-03-13 17:00:0003/13/2022 | London Knights | 17:00:005:00 pm EDT | Las Vegas Fury | N/A |
| 2022-03-13 17:20:0003/13/2022 | Tulsa Desperados | 17:20:005:20 pm EDT | Carolina Skyhawks | N/A |
| 2022-03-13 19:00:0003/13/2022 | Louisiana Revolution | 19:00:007:00 pm EDT | Charleston Predators | N/A |
| 2022-03-13 19:20:0003/13/2022 | Sioux Falls Sparrows | 19:20:007:20 pm EDT | Baltimore Vultures | N/A |
| 2022-03-13 21:00:0003/13/2022 | D.C. Dragons | 21:00:009:00 pm EDT | Denver Nightwings | N/A |
| 2022-03-13 21:20:0003/13/2022 | Houston Hyenas | 21:20:009:20 pm EDT | Los Angeles Lycans | N/A |
| 2022-03-14 19:15:0003/14/2022 | St. Louis Gladiators | 19:15:007:15 pm EDT | Florida Storm | N/A |
| 2022-03-19 12:00:0003/19/2022 | Jacksonville Kings | 12:00:0012:00 pm EDT | Tulsa Desperados | N/A |
| 2022-03-19 12:20:0003/19/2022 | Los Angeles Lycans | 12:20:0012:20 pm EDT | Fort Worth Toros | N/A |
| 2022-03-19 14:30:0003/19/2022 | Denver Nightwings | 14:30:002:30 pm EDT | Baltimore Vultures | N/A |
| 2022-03-19 15:00:0003/19/2022 | Charleston Predators | 15:00:003:00 pm EDT | Carolina Skyhawks | N/A |
| 2022-03-19 16:45:0003/19/2022 | Atlanta Swarm | 16:45:004:45 pm EDT | St. Louis Gladiators | N/A |
| 2022-03-19 17:15:0003/19/2022 | Houston Hyenas | 17:15:005:15 pm EDT | Portland Fleet | N/A |
| 2022-03-20 17:00:0003/20/2022 | D.C. Dragons | 17:00:005:00 pm EDT | Arizona Scorpions | N/A |
| 2022-03-20 17:20:0003/20/2022 | Las Vegas Fury | 17:20:005:20 pm EDT | Queen City Corsairs | N/A |
| 2022-03-20 19:00:0003/20/2022 | Lone Star Glory | 19:00:007:00 pm EDT | Vancouver Legion | N/A |
| 2022-03-20 19:20:0003/20/2022 | London Knights | 19:20:007:20 pm EDT | Sioux Falls Sparrows | N/A |
| 2022-03-20 21:00:0003/20/2022 | Florida Storm | 21:00:009:00 pm EDT | Louisiana Revolution | N/A |
| 2022-03-20 21:20:0003/20/2022 | San Diego Mavericks | 21:20:009:20 pm EDT | Mexico City Aztecs | N/A |
| 2022-03-26 14:30:0003/26/2022 | Arizona Scorpions | 14:30:002:30 pm EDT | London Knights | N/A |
| 2022-03-26 15:00:0003/26/2022 | St. Louis Gladiators | 15:00:003:00 pm EDT | Jacksonville Kings | N/A |
| 2022-03-26 16:45:0003/26/2022 | Vancouver Legion | 16:45:004:45 pm EDT | Los Angeles Lycans | N/A |
| 2022-03-26 17:15:0003/26/2022 | Carolina Skyhawks | 17:15:005:15 pm EDT | Atlanta Swarm | N/A |
| 2022-03-27 19:00:0003/27/2022 | Las Vegas Fury | 19:00:007:00 pm EDT | Baltimore Vultures | N/A |
| 2022-03-27 19:20:0003/27/2022 | Tulsa Desperados | 19:20:007:20 pm EDT | Florida Storm | N/A |
| 2022-03-27 21:00:0003/27/2022 | San Diego Mavericks | 21:00:009:00 pm EDT | Houston Hyenas | N/A |
| 2022-03-27 21:20:0003/27/2022 | Queen City Corsairs | 21:20:009:20 pm EDT | Sioux Falls Sparrows | N/A |
| 2022-03-28 19:15:0003/28/2022 | Fort Worth Toros | 19:15:007:15 pm EDT | Lone Star Glory | N/A |
| 2022-04-02 14:30:0004/02/2022 | Atlanta Swarm | 14:30:002:30 pm EDT | Florida Storm | N/A |
| 2022-04-02 15:00:0004/02/2022 | Denver Nightwings | 15:00:003:00 pm EDT | Queen City Corsairs | N/A |
| 2022-04-02 16:45:0004/02/2022 | Houston Hyenas | 16:45:004:45 pm EDT | Mexico City Aztecs | N/A |
| 2022-04-02 17:15:0004/02/2022 | San Diego Mavericks | 17:15:005:15 pm EDT | Portland Fleet | N/A |
| 2022-04-03 19:00:0004/03/2022 | Baltimore Vultures | 19:00:007:00 pm EDT | D.C. Dragons | N/A |
| 2022-04-03 19:20:0004/03/2022 | Louisiana Revolution | 19:20:007:20 pm EDT | Jacksonville Kings | N/A |
| 2022-04-03 21:00:0004/03/2022 | Charleston Predators | 21:00:009:00 pm EDT | St. Louis Gladiators | N/A |
| 2022-04-03 21:20:0004/03/2022 | Arizona Scorpions | 21:20:009:20 pm EDT | Las Vegas Fury | N/A |
| 2022-04-09 12:00:0004/09/2022 | Charleston Predators | 12:00:0012:00 pm EDT | Atlanta Swarm | N/A |
| 2022-04-09 12:20:0004/09/2022 | Queen City Corsairs | 12:20:0012:20 pm EDT | London Knights | N/A |
| 2022-04-09 14:30:0004/09/2022 | Las Vegas Fury | 14:30:002:30 pm EDT | D.C. Dragons | N/A |
| 2022-04-09 15:00:0004/09/2022 | Los Angeles Lycans | 15:00:003:00 pm EDT | Mexico City Aztecs | N/A |
| 2022-04-09 16:45:0004/09/2022 | Baltimore Vultures | 16:45:004:45 pm EDT | Arizona Scorpions | N/A |
| 2022-04-09 17:15:0004/09/2022 | Florida Storm | 17:15:005:15 pm EDT | Jacksonville Kings | N/A |
| 2022-04-10 17:00:0004/10/2022 | Carolina Skyhawks | 17:00:005:00 pm EDT | St. Louis Gladiators | N/A |
| 2022-04-10 17:20:0004/10/2022 | Sioux Falls Sparrows | 17:20:005:20 pm EDT | Denver Nightwings | N/A |
| 2022-04-10 19:00:0004/10/2022 | Portland Fleet | 19:00:007:00 pm EDT | Fort Worth Toros | N/A |
| 2022-04-10 19:20:0004/10/2022 | Louisiana Revolution | 19:20:007:20 pm EDT | Tulsa Desperados | N/A |
| 2022-04-10 21:00:0004/10/2022 | Lone Star Glory | 21:00:009:00 pm EDT | San Diego Mavericks | N/A |
| 2022-04-10 21:20:0004/10/2022 | Houston Hyenas | 21:20:009:20 pm EDT | Vancouver Legion | N/A |
| 2022-04-15 17:00:0004/15/2022 | D.C. Dragons | 17:00:005:00 pm EDT | London Knights | N/A |
| 2022-04-15 17:20:0004/15/2022 | Vancouver Legion | 17:20:005:20 pm EDT | San Diego Mavericks | N/A |
| 2022-04-15 19:00:0004/15/2022 | St. Louis Gladiators | 19:00:007:00 pm EDT | Louisiana Revolution | N/A |
| 2022-04-15 19:20:0004/15/2022 | Atlanta Swarm | 19:20:007:20 pm EDT | Tulsa Desperados | N/A |
| 2022-04-15 21:00:0004/15/2022 | Arizona Scorpions | 21:00:009:00 pm EDT | Sioux Falls Sparrows | N/A |
| 2022-04-15 21:20:0004/15/2022 | Mexico City Aztecs | 21:20:009:20 pm EDT | Lone Star Glory | N/A |
| 2022-04-16 12:00:0004/16/2022 | Jacksonville Kings | 12:00:0012:00 pm EDT | Carolina Skyhawks | N/A |
| 2022-04-16 12:20:0004/16/2022 | Fort Worth Toros | 12:20:0012:20 pm EDT | Houston Hyenas | N/A |
| 2022-04-16 14:30:0004/16/2022 | Los Angeles Lycans | 14:30:002:30 pm EDT | Portland Fleet | N/A |
| 2022-04-16 15:00:0004/16/2022 | Queen City Corsairs | 15:00:003:00 pm EDT | Baltimore Vultures | N/A |
| 2022-04-16 16:45:0004/16/2022 | Las Vegas Fury | 16:45:004:45 pm EDT | Denver Nightwings | N/A |
| 2022-04-16 17:15:0004/16/2022 | Florida Storm | 17:15:005:15 pm EDT | Charleston Predators | N/A |
